Drug Administration Routes

New drug administration routes study results reported from L. Zhou et al

Published in Drug Week, May 14th, 2010

According to a study from the United States, "The disposition of stavudine, a potent and orally active nucleoside reverse transcriptase inhibitor, was investigated in six healthy human subjects. Before dosing humans with [1'-C-14] stavudine, a tissue distribution study was performed in Long-Evans rats."

"from this study showed no accumulation of radioactivity in any of the tissues studied, indicating that the position of the C-14-label on the molecule was appropriate for the human study. After a single 80-mg (100 mu Ci) oral dose of [1'-C-14] stavudine, approximately 95% of the radioactive dose was excreted in urine with an elimination half-life of 2.35 h. Fecal...

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Source: Drug Week (2010-05-14)

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