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Drug Development

Data on drug development published by L.Q. Cong and colleagues

Published in Drug Week, July 2nd, 2010

According to a study from Shanghai, People's Republic of China, "A series of novel 5'-deoxy-4'-thio-l-nucleosides was designed and synthesized."

"The absolute configuration of the target compound 23 alpha was confirmed by X-ray crystallography," wrote L.Q. Cong and colleagues.

The researchers concluded: "The antitumor activities of the target compounds were tested against the growth of human carcinoma of colon (LOVO), human leukemia cell line (CEM) and human breast cancer cell line (MDA-MB-435) cells in vitro. 6-cyclopentylamino and 6-cyclohexylamino purine compounds 26 and 27, both in alpha-configuration and in beta-form, exhibited strong inhibition...

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