Cancer
Research on cancer detailed by scientists at University of British Columbia, Child and Family Research Institute
Published in Drug Week, October 15th, 2010
Scientists discuss in 'Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability' new findings in cancer. "The Y-box binding protein-1 (YB-1) is an oncogenic transcription/translation factor that is activated by phosphorylation at S102 whereby it induces the expression of growth promoting genes such as EGFR and HER-2. We recently illustrated by an in vitro kinase assay that a novel peptide to YB-1 was highly phosphorylated by the serine/threonine p90 S6 kinases RSK-1 and RSK-2, and to a lesser degree PKCa and AKT," scientists in Vancouver, Canada report.
"Herein, we sought to develop...
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Source: Drug Week (2010-10-15)
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