Research on osteoporosis discussed by scientists at Mater Misericordiae University

Researchers detail in 'Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation,' new data in osteoporosis. According to recent research published in the journal Bmc Musculoskeletal Disorders, "The Wnt/ß-catenin pathway is a major signaling cascade in bone biology, playing a key role in bone development and remodeling. The objectives of this study were firstly, to determine the effects of dexamethasone exposure on Wnt/ß-catenin signaling at an intracellular and transcriptional level, and secondly, to assess the phenotypic effects of silencing the Wnt antagonist, Dickkopf-1 (Dkk1) in the setting of dexamethasone...

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