Data on central nervous system depressants described by researchers at State University of New York, Department of Anesthesiology

Scientists discuss in 'Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brain' new findings in central nervous system depressants. "Most studies of the effect of cocaine on brain activity in laboratory animals are preformed under anesthesia, which could potentially affect the physiological responses to cocaine. Here we assessed the effects of two commonly used anesthetics [alpha-chloralose (alpha-CHLOR) and isofluorane (ISO)] on the effects of acute cocaine (1 mg/kg i.v.) on cerebral blood flow (CBF), cerebral blood volume (CBV), and tissue hemoglobin oxygenation (S(t)O(2)) using optical techniques and cocaine's pharmacokinetics (PK) and...

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