Nephrology
New findings from Texas Southern University, Center for Cardiovascular Disease describe advances in nephrology
Published in Drug Week, November 19th, 2010
Researchers detail in 'Renal function and vasomotor activity in mice lacking the Cyp4a14 gene,' new data in nephrology. According to recent research from the United States, "The production of 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney is thought to be involved in the control of renal vascular tone and tubular sodium and chloride reabsorption. Cytochrome (Cyp) P-450 enzymes of the Cyp4a family in the mouse, namely 4a10, -12 and 14, are involved in 20-HETE synthesis."
"Recent advances in the molecular genetics of the mouse have produced mice in which Cyp4a isoforms have been disrupted and the consequence of such an approach is examined. This study evaluated...
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Source: Drug Week (2010-11-19)
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