Depression

Scientists at Institute of Cytology and Genetics target depression

Published in Drug Week, December 10th, 2010

2010 DEC 10 -- Data detailed in 'Targeting tryptophan hydroxylase 2 in affective disorder' have been presented. According to a study from Russia, "Serotonin (5-HT) has been implicated in several psychiatric disorders including schizophrenia, depressive disorder and suicide. The key and rate limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2)."

"The association between TPH2 and affective disorders as well as future vistas of its potential clinical targeting: i) TPH2 in the regulation of 5-HT-dependent behavior, ii) TPH2 gene polymorphism and human behavior, iii) TPH2 and sensitivity to antidepressants and iv) effect of dietary tryptophan...

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Source: Drug Week (2010-12-10)

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