Cancer Therapy
New findings from K. Kirschner and co-authors describe advances in cancer therapy
Published in Drug Week, December 10th, 2010
2010 DEC 10 -- Fresh data on cancer therapy are presented in the report 'Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs.' According to recent research from Cambridge, the United Kingdom, "In this review, we focus on the discrepant roles of the DNA repair complex ERCC1/XPF in the prevention of cancer and in the resistance of cancer to chemotherapy. ERCC1/XPF is essential for nucleotide excision repair (NER) incising DNA 5' to the lesion."
"NER deficiency results in the skin cancer-prone inherited disease xeroderma pigmentosum (XP). The ERCC1/XPF complex is also involved in recombination, double strand break...
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Source: Drug Week (2010-12-10)
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