Cholinesterases

Reports from O. Soukup et al highlight recent research in cholinesterases

Published in Drug Week, December 24th, 2010

2010 DEC 24 -- "The oxime reactivator K112 is a member of the new group of xylene linker-containing AChE reactivators. Its cholinergic properties could be of importance at OP poisoning and are not related to the AChE reactivation that has been studied," scientists writing in the journal Biomedicine & Pharmacotherapy report.

"It has been found that, despite of reactivating potency, this compound has additional effects. These cholinergic effects include a weak inhibition of AChE (IC50 = 43.8 +/- 4.88 mc M), inhibition of binding to the porcine muscarinic M2 receptor (IC50 = 4.36 mc M) and finally, the inhibition of HACU (68.4 +/- 9.9%), a key...

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Source: Drug Week (2010-12-24)

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