Medicinal Chemistry
Researchers from California Institute of Technology, Institute of Technology describe findings in medicinal chemistry
Published in Drug Week, December 31st, 2010
2010 DEC 31 -- A report, 'Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture,' is newly published data in Journal of Medicinal Chemistry. According to recent research from the United States, "Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture. Gene regulation by polyamides requires efficient cellular uptake and nuclear localization properties for candidate compounds."
"To further optimize Py-Im polyamides for enhanced potency in cell culture, a focused library of polyamides...
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Source: Drug Week (2010-12-31)
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