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Receptor Protein-Tyrosine Kinases

Recent studies by Q. Wei and co-authors add new data to receptor protein-tyrosine kinases findings

Published in Drug Week, January 14th, 2011

2011 JAN 14 -- Current study results from the report, 'EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy,' have been published. "Members of the epidermal growth factor receptor, EGFR, family are interesting as targets for radionuclide therapy using targeting agents labeled with a-or ß-emitting radionuclides, especially when EGFR-positive colorectal carcinomas, CRC, are resistant to EGFR inhibiting agents like cetuximab and various tyrosine kinase inhibitors. The expression of EGFR, HER2 and HER3 was therefore analyzed in CRC samples from primary tumors, corresponding lymph node...

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