Drug Development

Data from China Pharmaceutical University advance knowledge in drug development

Published in Drug Week, January 14th, 2011

2011 JAN 14 -- According to recent research published in the journal Drug Metabolism and Disposition, "P-glycoprotein (P-gp) is an ATP-dependent efflux transporter highly expressed in gastrointestinal tract and multidrug resistance tumor cells. Inhibition or induction of P-gp can cause drug-drug interactions and thus influence the effects of P-gp substrate drugs."

"Previous studies indicated that 20(S)-ginsenoside Rh2 [20(S)-Rh2] could synergistically enhance the anticancer effects of conventional chemotherapeutic agents at a nontoxic dose. The aim of present study was to investigate in vitro and in vivo whether 20(S)Rh2 was a P-gp inhibitor and...

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Source: Drug Week (2011-01-14)

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