Drug Development

Data on drug development published by C.V. Pastuskovas and colleagues

Published in Drug Week, January 14th, 2011

2011 JAN 14 -- "3A5 is a novel antibody that binds repeated epitopes within CA125, an ovarian tumor antigen that is shed into the circulation. Binding to shed antigen may limit the effectiveness of therapeutic antibodies because of unproductive immune complex (IC) formation and/or altered antibody distribution," investigators in the United States report.

"To evaluate this possibility, we characterized the impact of shed CA125 on the in vivo distribution of 3A5. In vitro, 3A5 and CA125 were found to form ICs in a concentration-dependent manner. This phenomenon was then evaluated in vivo using quantitative whole-body autoradiography to assess the tissue...

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Source: Drug Week (2011-01-14)

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