Research Conducted at University of Oxford Has Provided New Information about Antibiotics

2011 JAN 21 -- New investigation results, 'Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms,' are detailed in a study published in Jmb Online. According to recent research published in the journal Jmb Online, "We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important ß-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl complexes are very similar; however, variations in the orientation of the amino-terminal membrane-proximal...

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