Research Data from J.O. Hahn and Colleagues Update Understanding of Central Nervous System Depressants

2011 JAN 21 -- A new study, 'Closed-loop anesthetic drug concentration estimation using clinical-effect feedback,' is now available. "This letter presents a novel closed-loop approach to anesthetic drug concentration estimation using clinical-effect measurement feedback. Compared with the open-loop prediction used in current target-controlled infusion systems, closed-loop estimation exploits the discrepancy between the measured and predicted clinical effects to make corrections to the drug-concentration estimate, achieving improved robustness against variability in the patient pharmacokinetics and pharmacodynamics," scientists in Edmonton, Canada report.

"A...

Want to see the full article?

• Purchase this article for only $3.00