Researchers from Medical College of Georgia, Department of Physiology Report on Findings in Intercellular Signaling Peptides and Proteins

2011 JAN 21 -- Researchers detail in 'O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1,' new data in Intercellular Signaling Peptides and Proteins. "O-GlcNAcylation augments vascular contractile responses, and O-GlcNAc-proteins are increased in the vasculature of deoxycorticosterone-acetate salt rats. Because endothelin 1 (ET-1) plays a major role in vascular dysfunction associated with salt-sensitive forms of hypertension, we hypothesized that ET-1-induced changes in vascular contractile responses are mediated by O-GlcNAc modification of proteins," researchers in the United States report.

"Incubation of rat aortas with...

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