Pharmacokinetics
Researchers from University of California Describe Findings in Pharmacokinetics
Published in Drug Week, January 21st, 2011
2011 JAN 21 -- A new study, 'Clearance (nee Rowland) concepts: a downdate and an update,' is now available. "A number of experimental observations in the late 1960s, early 1970s could not be explained by the pharmacokinetic theory available at that time. For example rats receiving phenobarbital as an enzyme inducing agent exhibited increased elimination of phenylbutazone in vitro in liver microsomes and in vivo in whole animals compared to that observed in non-induced animals," researchers in the United States report.
"However, for desipramine, although phenobarbital increased elimination in microsomes, no change in plasma disappearance was noted in vivo...
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Source: Drug Week (2011-01-21)
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