Intercellular Signaling Peptides and Proteins
Scientists at La Jolla Institute for Allergy and Immunology Discuss Research in Intercellular Signaling Peptides and Proteins
Published in Drug Week, January 21st, 2011
2011 JAN 21 -- Investigators publish new data in the report 'Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.' According to recent research published in the Journal of Immunology, "Certain glycolipid Ags for Valpha14i NKT cells can direct the overall cytokine balance of the immune response. Th2-biasing OCH has a lower TCR avidity than the most potent agonist known, alpha-galactosylceramide."
"Although the CD1d-exposed portions of OCH and alpha-galactosylceramide are identical, structural analysis indicates that there are subtle CD1d conformational differences due to differences in the buried lipid portion of...
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Source: Drug Week (2011-01-21)
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