Huntington Disease

New Findings Reported from Lund University Describe Advances in Huntington Disease

Published in Drug Week, January 21st, 2011

2011 JAN 21 -- "Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been thought to account for the characteristic psychiatric symptoms, cognitive decline and motor dysfunction," scientists writing in the journal Acta Neuropathologica report.

"However, the homeostatic control of emotions and metabolism are disturbed early in HD, and focused studies have identified a loss of orexin (hypocretin) neurons in the lateral hypothalamus in HD patients. There has been limited assessment of other hypothalamic cell populations that may be involved....

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Source: Drug Week (2011-01-21)

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