Published in Drug Week, January 21st, 2011
"Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated," wrote M.S. Duan and colleagues, GlaxoSmithKline.
The researchers concluded: "Structure-activity relationship (SAR) derived from these studies further guided the optimization efforts, ultimately leading to the discovery of 36 with an acceptable drug-like profile."
Duan and colleagues published their study in Bioorganic & Medicinal...
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