Melanomas
New Melanomas Research from University of Tennessee Discussed
Published in Drug Week, January 21st, 2011
2011 JAN 21 -- "Cyclic phosphatidic acid (CPA) is a naturally occurring analog of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a five-membered ring with the sn-3 phosphate. Here, we describe the synthesis of R-3-CCPA and S-3-CCPA along with their pharmacological properties as inhibitors of lysophospholipase D/autotaxin, agonists of the LPA(5) GPCR, and blockers of lung metastasis of B16-F10 melanoma cells in a C57BL/6 mouse model," researchers in the United States report.
"S-3CCPA was significantly more efficacious in the activation of LPA5 compared to the R-stereoisomer. In contrast, no stereoselective differences were found between...
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Source: Drug Week (2011-01-21)
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