Reactive Nitrogen Species
Reports Outline Reactive Nitrogen Species Study Findings from University of Sao Paulo
Published in Drug Week, January 21st, 2011
2011 JAN 21 -- According to a study from Ribeirao Preto, Brazil, "7-Nitroindazole (7-NI) inhibits neuronal nitric oxide synthase in vivo and reduces l-DOPA-induced dyskinesias in a rat model of parkinsonism. The aim of the present study was to determine if the anti-dyskinetic effect of 7-NI was subject to tolerance after repeated treatment and if this drug could interfere with the priming effect of l-DOPA."
"Adult male Wistar rats (200-250 g) with unilateral depletion of dopamine in the substantia nigra compacta were treated with l-DOPA (30 mg/kg) for 34 days. On the 1st day, 6 rats received ip saline and 6 received ip 7-NI (30 mg/kg) before l-DOPA. From...
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Source: Drug Week (2011-01-21)
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