Tegmentum Mesencephali

Research from J. Kaufling et al Broadens Understanding of Tegmentum Mesencephali

Published in Drug Week, January 21st, 2011

2011 JAN 21 -- "The tail of the ventral tegmental area (tVTA), also called the rostromedial tegmental nucleus, is a newly defined brain structure and a potential control centre for dopaminergic activity. It was identified by the induction of DeltaFosB following chronic cocaine exposure," scientists writing in the British Journal of Pharmacology report.

"In this work, we screened 20 drugs for their ability to induce FosB/DeltaFosB in the tVTA. EXPERIMENTAL APPROACH Immunohistochemistry following systemic drug administration was used to study FosB/DeltaFosB induction in the tVTA of adult rats. Double-staining was used to determine whether dopamine or...

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Source: Drug Week (2011-01-21)

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