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Leukemia

Researchers from University of Western Australia Detail New Studies and Findings in the Area of Leukemia

Published in Drug Week, January 21st, 2011

2011 JAN 21 -- "Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently observed that GC resistance in T-ALL cell lines is associated with a proliferative metabolism and reduced expression of MLL," scientists writing in the journal Molecular Cancer report.

"In this study we have further explored the relationship between MLL status and GC sensitivity. Negative correlation of MLL expression with GC resistance in 15 T-ALL cell lines was confirmed by quantitative RT-PCR. The absence of...

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