Pharmaceutical and Pharmacology

Studies from A. Dey et al Have Provided New Data on Pharmaceutical and Pharmacology

Published in Drug Week, January 21st, 2011

2011 JAN 21 -- Researchers in Parkville, Australia conducted a study "To investigate the role of connexin 43 in the maintenance of spontaneous activity in prostate tissue from young and old guinea pigs. EXPERIMENTAL APPROACH Conventional intracellular microelectrode and tension recording techniques, coupled with Western blot analysis and immunohistochemistry for connexin 43 (CX43) were used."

"The effects of three gap junction uncouplers, 18 beta glycyrrhetinic acid (10 mc M, 40 mc M), carbenoxolone (10 mc M, 50 mc M) and octanol (0.5 mM, 1 mM), were studied in cells displaying slow wave activity and on spontaneously contracting tissue from prostate glands...

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Source: Drug Week (2011-01-21)

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