Apoptosis

Studies from University of Barcelona Update Current Data on Apoptosis

Published in Drug Week, January 21st, 2011

2011 JAN 21 -- "In the present study the role of JAK/STAT and Akt in apoptosis was evaluated in cerebellar granule cells after treatment with the mitochondrial toxin MPP+. Firstly, we evaluated the role of the prosurvival Akt pathway in MPP+-induced apoptosis and found that MPP+ rapidly reduced the phosphorylation of Akt at Ser473," scientists in Barcelona, Spain report.

"Since PTEN is an upstream regulator of Akt, its inhibition with bpV(pic) (1-30 mc M) should activate Akt, however, it did not attenuate CGC cell death mediated by MPP+ but protected CGC from apoptosis mediated by S/K deprivation. We also demonstrated that after the treatment with the...

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Source: Drug Week (2011-01-21)

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