Amines
Studies from A. Kruczynski and Colleagues Yield New Information about Amines
Published in Drug Week, February 4th, 2011
2011 FEB 4 -- Research findings, 'Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system,' are discussed in a new report. According to a study from France, "We have exploited the polyamine transport system (PTS) to deliver selectively a spermine-drug conjugate, F14512 to cancer cells. This study was aimed to define F14512 anticancer efficacy against tumor models and to investigate whether fluorophor-labeled polyamine probes could be used to identify tumors expressing a highly active PTS and that might be sensitive to F14512 treatments."
"Eighteen tumor models were used to assess F14512 antitumor activity....
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Source: Drug Week (2011-02-04)
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