Dipeptides

New Dipeptides Research from K. Mackovicova and Colleagues Discussed

Published in Drug Week, May 20th, 2011

2011 MAY 20 -- "Angiotensin II can induce cardiac hypertrophy by stimulating the release of growth factors. ACE inhibitors reduce angiotensin II levels and cardiac hypertrophy, but their effects on the healthy heart are largely unexplored," scientists in Bratislava, Slovakia report.

"We hypothesized that ACE inhibition decreases left ventricular mass in normotensive animals and that this is associated with altered expression of cardiac fetal genes, growth factors, and endothelial nitric oxide synthase (eNOS). Wistar rats (n = 7 per group) were orally administered with enalapril twice daily for a total daily dose of 5 mg.kg(-1).d(-1) (ENAP5) or 15...

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Source: Drug Week (2011-05-20)

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