Metalloporphyrins

Reports Outline Metalloporphyrins Study Results from Konkuk University

Published in Drug Week, June 24th, 2011

2011 JUN 24 -- According to a study from Seoul, South Korea, "Lanosterol 14 alpha-demethylase (CYP51F1) from Candida albicans is known to be an essential enzyme in fungal sterol biosynthesis. Wild-type CYP51F1 and several of its mutants were heterologously expressed in Escherichia coli, purified, and characterized."

"It exhibited a typical reduced CO-difference spectrum with a maximum at 446 nm. Reconstitution of CYP51F1 with NADPH-P450 reductase gave a system that successfully converted lanosterol to its demethylated product. Titration of the purified enzyme with lanosterol produced a typical type I spectral change with K-d = 6.7 mc M. The azole antifungal...

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Source: Drug Week (2011-06-24)

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