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Epilepsy

Study Results from Georgetown University Broaden Understanding of Epilepsy

Published in Drug Week, July 29th, 2011

2011 JUL 29 -- A new study, "Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure," is now available. According to the authors of recent research from Washington, District of Columbia, "Antiepileptic drugs (AEDs) such as phenobarbital, phenytoin, and valproic acid, when given in therapeutic doses to neonatal rats, cause pronounced neuronal apoptotic cell death. This effect is especially pronounced in the striatum and cortex during the second postnatal week, a period corresponding to the 'brain growth spurt' (third trimester of gestation and early infancy) in humans."

"Of particular concern is the fact that...

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