Immunoglobulins

Studies from Amgen in the Area of Immunoglobulins Described

Published in Drug Week, July 29th, 2011

2011 JUL 29 -- According to the authors of a study from Thousand Oaks, California, "The administration of biological therapeutics may result in the development of anti-drug antibodies (ADAs) in treated subjects. In some cases. ADA responses may result in the loss of therapeutic efficacy due to the formation of neutralizing ADAs (NAbs)."

"An important characteristic of anti-drug NAbs is their direct inhibitory effect on the pharmacological activity of the therapeutic. Neutralizing antibody responses are of particular concern for biologic products with an endogenous homolog whose activity can be potentially dampened or completely inhibited by the NAbs leading...

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Source: Drug Week (2011-07-29)

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