Diabetes Insipidus
Researchers at University of Aarhus Publish New Data on Diabetes Insipidus
Published in Drug Week, September 9th, 2011
2011 SEP 9 -- "In the kidney, the actions of vasopressin on its type-2 receptor (V2R) induce increased water reabsorption alongside polyphosphorylation and membrane targeting of the water channel aquaporin-2 (AQP2). Loss-of-function mutations in the V2R cause X-linked nephrogenic diabetes insipidus," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report.
"Treatment of this condition would require bypassing the V2R to increase AQP2 membrane targeting, but currently no specific pharmacological therapy is available. The present study examined specific E-prostanoid receptors for this...
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Source: Drug Week (2011-09-09)
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