Published in Drug Week, September 16th, 2011
"We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency. The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 mu g/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h. Intravenous bolus kisspeptin-10 resulted in a rapid and...
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