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Transcription Factors

New Findings in Transcription Factors Described from National Autonomous University

Published in Drug Week, October 14th, 2011

2011 OCT 14 -- According to the authors of recent research from Mexico City, Mexico, "Treatment of human gingival fibroblasts (HGFs) with lipoteichoic acid (LTA) results in the activation of multiple signaling pathways. Exposure of HGF to LTA has been shown to result in the activation of phosphatidylinositol 3-kinase (PI3K)."

"The aim of this study was to evaluate the effects of LTA-induced PI3K activation in HGFs. We found that LTA treatment results in the phosphorylation of Ala and glycogen synthase kinase (GSK-3). Inactivation of GSK-3 promotes the nuclear accumulation of beta-catenin and expression of connexin43. Treatment with PI3K inhibitors,...

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