Lung Cancer

Report Summarizes Lung Cancer Study Findings from National Cancer Institute

Published in Drug Week, October 14th, 2011

2011 OCT 14 -- "Small cell lung cancer (SCLC) is an aggressive lung cancer subtype in need of better therapies. Histone deacetylase inhibitors (HDIs) promote increased lysine acetylation in nucleosomal histones, and are thought to relax chromatin, thereby allowing increased access of transcription factors and DNA damaging agents alike to DNA," researchers in Bethesda, Maryland report.

"We studied whether two HDIs, belinostat and romidepsin, can be effectively combined with cisplatin or etoposide (VP-16) for SCLC cells. Analysis of cell survival and synergy was performed using CalcuSyn mathematical modeling to calculate a combination index. Immunostaining of...

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Source: Drug Week (2011-10-14)

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