Pharmaceutical Research
Researchers from University of London Report Recent Findings in Pharmaceutical Research
Published in Drug Week, October 14th, 2011
2011 OCT 14 -- According to the authors of recent research from London, United Kingdom, "Poorly water soluble basic drugs are very sensitive to pH changes and following dissolution in the acidic stomach environment tend to precipitate upon gastric emptying, which leads to compromised or erratic oral bioavailability. In this work, we show that the oral bioavailability of a model poorly soluble basic drug (cinnarizine) can be improved by drug encapsulation within highly pH-responsive microparticles (Eudragit L)."
"The latter was prepared by emulsion solvent evaporation which yielded discrete spherical microparticles (diameter of 56.4 +/- 6.8 mu m and a span...
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Source: Drug Week (2011-10-14)
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