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Doxorubicin Therapy

Studies from Zagazig University Add New Findings in the Area of Doxorubicin Therapy

Published in Drug Week, October 14th, 2011

2011 OCT 14 -- According to the authors of recent research published in the journal Brain Research Bulletin, "Doxorubicin (DOX) is considered one of the most important chemotherapeutic agents that is used for the treatment of solid tumors."

"Its long-term use can cause neurodegenerative disorders due to its prolonged activation of microglia. The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-alpha, iNOS and NF-kappa B expressions but also the increase in TNF-alpha and total nitrite levels in brain tissue when compared with rats treated with DOX-only," wrote R.H. Mohamed...

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