Synucleins

Study Data from University of California Provide New Insights into Synucleins

Published in Drug Week, November 25th, 2011

2011 NOV 25 -- "Increased intracellular levels of alpha-synuclein are implicated in Parkinson's disease and related disorders and may be caused by alterations in the ubiquitin-proteasome system (UPS) or the autophagy-lysosomal pathway (ALP). A critical question remains how alpha-synuclein is degraded by neurons in vivo," scientists in La Jolla, California report.

"To address this, our study uses alpha-synuclein transgenic mice, expressing human alpha-synuclein or alpha-synuclein-eGFP under the (h) PDGF-beta promoter, in combination with in vivo pharmacologic and multiphoton imaging strategies to systematically test degradation pathways in the living mouse...

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Source: Drug Week (2011-11-25)

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