Bile Pigments

New Bile Pigments Research Reported from R. Kundu and Co-Authors

Published in Drug Week, November 25th, 2011

2011 NOV 25 -- "Accumulation of bilirubin, primarily because of its insolubility, has been found to be associated with liver diseases including jaundice. Free bilirubin is insoluble; its glucuronidation by bilirubin-UGT enzyme (UGT1A1) makes it soluble and eliminates it through urine and faeces," researchers in Jorhat, India report.

"Taking CCl4 induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside. Although Cln is a flavone compound, it escaped self-glucuronidation in the intestine and readily absorbed. Kinetic...

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Source: Drug Week (2011-11-25)

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