Published in Drug Week, January 6th, 2012
"Rats were left 8 weeks or 12 weeks after STZ or fructose administration respectively. CA (20 mg kg(-1) day(-1)) was daily administered in the last 6 weeks. Then, blood pressure (BP) was recorded. Isolated Aorta reactivity to phenylephrine (PE), KCl, acetylcholine (ACh) was studied as well as nitric oxide (NO) generation plus Ca2+ influx. Insulin deficiency was associated with elevated BP, increased response to PE and KCl, decreased...
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