Prostate Cancer
New Findings in Prostate Cancer Described from University of California
Published in Drug Week, January 20th, 2012
2012 JAN 20 -- "The nucleoside 5-aminoimidazole-4-carboxamide riboside (AICAR) is a low-energy mimetic and adenosine monophosphate (AMP)-activated protein kinase (AMPK) agonist that can affect the phenotype of malignant cells by diminishing their anabolism. It does this by being converted to 5-aminoimidazole-4-carboxamide ribotide (ZMP), an AMP analog," scientists in Los Angeles, California report.
"We combined this promising antineoplastic agent with ionizing radiation in an attempt to increase its efficacy. The effect of AICAR on cell proliferation, cell viability, apoptosis, reactive oxygen species production, radiosensitivity, and AMPK activation was...
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Source: Drug Week (2012-01-20)
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