Diabetes

Studies Conducted at University of Minnesota on Diabetes Recently Published

Published in Drug Week, February 10th, 2012

2012 FEB 10 -- "G protein-coupled receptor 119 (GPR119) is predominantly expressed in beta cells and intestinal L cells. AR231453 is a selective small-molecular GPR119 agonist that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release," scientists in Minneapolis, Minnesota report.

"We investigated whether AR231453 can directly stimulate beta-cell replication and improve islet graft function in diabetic mice. A total of 100 syngenic C57BL16 mouse islets were transplanted under the left kidney of each chemically induced diabetic C57BL16 mouse. Starting from the day of transplantation, these recipients were given...

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Source: Drug Week (2012-02-10)

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