Mononuclear Phagocyte System
Research from Harvard School of Medicine Provides New Data on Mononuclear Phagocyte System
Published in Drug Week, March 16th, 2012
2012 MAR 16 -- Current study results from the report, "MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties," have been published. "Gut-associated dendritic cells (DC) synthesize all-trans retinoic acid, which is required for inducing gut-tropic lymphocytes. Gut-associated DC from MyD88(-/-) mice, which lack most TLR signals, expressed low levels of retinal dehydrogenases (critical enzymes for all-trans retinoic acid biosynthesis) and were significantly impaired in their ability to induce gut-homing T cells," investigators in Boston, Massachusetts report.
"Pretreatment of extraintestinal DC with a TLR1/2 agonist was...
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Source: Drug Week (2012-03-16)
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