Peptides and Proteins
Scientists at Genomics Research Center Describe Research in Peptides and Proteins
Published in Drug Week, March 16th, 2012
2012 MAR 16 -- Current study results from the report, "Folding stability of amyloid-beta 40 monomer is an important determinant of the nucleation kinetics in fibrillization," have been published. "Amyloid formation is initiated by protein misfolding, followed by self-association to ultimately form amyloid fibrils. The discovery of toxic prefibrillar oligomers in many amyloidosis underscores the importance of understanding the folding mechanism prior to such aggregation," scientists in Taipei, Taiwan report.
"Here, we investigated the folding properties of the natively unfolded amyloid-ß (Aß) peptide and the familial variants (A21G, E22Q, E22G,...
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Source: Drug Week (2012-03-16)
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