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Immunoglobulins

Study Data from Amgen Update Understanding of Immunoglobulins

Published in Drug Week, March 16th, 2012

2012 MAR 16 -- A report, "General LC-MS/MS Method Approach to Quantify Therapeutic Monoclonal Antibodies Using a Common Whole Antibody Internal Standard with Application to Preclinical Studies," is newly published data in Analytical Chemistry. According to the authors of recent research from Thousand Oaks, California, "Ligand binding assays (LBAs) are widely used for therapeutic monoclonal antibody (mAb) quantification in biological samples. Major limitations are long method development times, reagent procurement, and matrix effects."

"LC-MS/MS methods using signature peptides are emerging as an alternative approach, which typically use a stable...

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