Hormones

Data on Hormones Reported by M. Martinez-Alfaro and Co-Researchers

Published in Drug Week, April 6th, 2012

2012 APR 6 -- "Lead exposure induces DNA damage, oxidative stress, and apoptosis, and alters DNA repair. We investigated the effects of melatonin co-administered to rats during exposure to lead," investigators in Mexico City, Mexico report.

"Three doses of lead acetate (10,50 and 100 mg/kg/day) were administered to rats during a 6-week period. Lymphocytes were analyzed. Lead exposure decreased glutathione (GSH) levels in blood, and at doses of 100 mg/kg/day and 50 mg/kg/day without melatonin, caused high levels of DNA damage, induced apoptosis, and altered DNA repair. Melatonin co-treatment did not attenuate the effects of lead at 100 mg/kg/day, indicating...

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Source: Drug Week (2012-04-06)

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