Published in Drug Week, April 6th, 2012
"Three doses of lead acetate (10,50 and 100 mg/kg/day) were administered to rats during a 6-week period. Lymphocytes were analyzed. Lead exposure decreased glutathione (GSH) levels in blood, and at doses of 100 mg/kg/day and 50 mg/kg/day without melatonin, caused high levels of DNA damage, induced apoptosis, and altered DNA repair. Melatonin co-treatment did not attenuate the effects of lead at 100 mg/kg/day, indicating...
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