Research Results from University of Debrecen Update Understanding of Parkinson's Disease

2012 MAY 4 -- A new study, "The decrease of dopamine D(2)/D(3) receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB(1) cannabinoid receptors in Parkinson's disease: A preliminary autoradiographic study with the selective dopamine D(2)/D(3) antagonist [(3)H]raclopride and the novel CB(1) inverse agonist [(125)I]SD7015," is now available. According to the authors of recent research published in the journal Brain Research Bulletin, "Cannabinoid type-1 receptors (CB(1)Rs) modulate synaptic neurotransmission by participating in retrograde signaling in the adult brain. Increasing evidence suggests that cannabinoids through CB(1)Rs...

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