HIV/AIDS
Researchers from Florida International University Report on Findings in HIV/AIDS
Published in Drug Week, May 4th, 2012
2012 MAY 4 -- Researchers detail in "HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)," new data in HIV/AIDS. "Histone deacetylases (HDACs) play a pivotal role in epigenetic regulation of transcription and homeostasis of protein acetylation in histones and other proteins involved in chromatin remodeling. Histone hypoacetylation and transcriptional dysfunction have been shown to be associated with a variety of neurodegenerative diseases," scientists in Miami, Florida report.
"More recently, neuron specific overexpression of HDAC2 has been shown to modulate...
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Source: Drug Week (2012-05-04)
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