M.D. Anderson Cancer Center

PTEN gene therapy treats prostate cancer alone and with other agents

Published in Elder Law Weekly, June 22nd, 2005

PTEN gene therapy treats prostate cancer alone and with other agents.

"The PTEN gene, located on chromosome 10, is a phosphatase in the phosphatidylinositol 3'-kinase (PI3'K)-mediated signal transduction pathway. PTEN inhibits the activation of Akt, a serine-threonine kinase involved in proliferative metabolic and antiapoptotic pathways, and has tumor suppressor properties," scientists in the United States report.

"We used a PTEN adenoviral vector, Ad-MMAC, to assess the role of PTEN in the treatment of prostate cancer," described M. Tanaka and colleagues, University of Texas, M.D. Anderson Cancer Therapy.

"Infection of Ad-MMAC in...

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Source: Elder Law Weekly (2005-06-22)

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