Elder Law Weekly
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Hopital La Pitie Salpetriere, Paris
Gi/o dependent mechanism is behind clozapine downregulation of TH in PC12 cells
October 26th, 2005
Gi/Go protein-dependent presynaptic mechanisms are involved in clozapine-induced downregulation of tyrosine hydroxylase in PC12 cells. According to a study from France, "Although the clinical effects of antipsychotics have been extensively studied, the molecular mechanisms underlying their antipsychotic activity are unclear. Chronic clozapine has been reported to significantly reduce the expression of tyrosine hydroxylase (TH) in the mesolimbic system." "To characterize the mechanisms of action of clozapine on TH expression, PC12 cells turned out to be a useful model, being by far less complex than the entire brain," proposed P. Tejedor-Real and...
Source: Elder Law Weekly (2005-10-26)
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